Syringoma are non-cancerous and harmless tumors that are believed to arise from eccrine ducts. Clear cell syringomas have a similar clinical presentation as other common syringomas and usually appears as papules on eyelids, although other sites may also be involved. The only features that differenciate clear-cell syringoma may be the presence of diabetes mellitus in most of the patients.
They are generally asymptomatic and present as flesh-colored or brown-purple papules. Research suggest that there is a high association between diabetes mellitus and clear-cell syringoma. Although they are clinically similar with other syringomas, their histopathology findings can be confused with metastatic clear cell syringoid carcinoma and balloon cell melanoma. So, to exclude other confusions an immunohistochemical analysis may be required.